This refers to applying mobilizations to joints at varying degrees of needed intensity. If gentle mobilizations are required to heal the patient, that is what is performed for the patient. If the joint needs a stronger movement (aggressive mobilization or manipulation), it can be performed in effective ways with varying speeds and amplitudes, including a small amplitude/high velocity therapeutic movement within or at end range of motion. Manipulation can lead to rapid reduction in pain. Often, as evidence-based medicine shows, skilled therapeutic interventions and education in combination are required to gain long-term benefits of the manipulation. When performed appropriately, manipulation provided by a physical therapist can make a significant difference in the treatment of pain and range of motion.